0
TECHNICAL PAPERS

Modeling Interstitial Flow in an Artery Wall Allows Estimation of Wall Shear Stress on Smooth Muscle Cells

[+] Author and Article Information
D. M. Wang, J. M. Tarbell

Physiological Transport Studies Laboratory, Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802

J Biomech Eng 117(3), 358-363 (Aug 01, 1995) (6 pages) doi:10.1115/1.2794192 History: Received September 21, 1993; Revised August 31, 1994; Online October 30, 2007

Abstract

The arterial media is modeled as a periodic array of cylindrical smooth muscle cells residing in a matrix comprised of proteoglycan and collagen fibers. Using Brinkman’s model to describe transmural flow through such a fibrous media, we calculate the effective hydraulic permeability of the media and the wall shear stress on smooth muscle cells. Two interesting results are obtained: first, the wall shear stress on smooth muscle cells is on the order of 1 dyne/cm2 , which is in the range known to affect endothelial cells in vitro; second, the flow resistance due to smooth muscle cells is not negligible compared to the resistance due to the fiber matrix.

Copyright © 1995 by The American Society of Mechanical Engineers
Your Session has timed out. Please sign back in to continue.

References

Figures

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In