Estimation of Cerebral Blood Flow From Thermal Measurement

[+] Author and Article Information
Datong Wei

Department of Neurosciences, The Cleveland Clinic Foundation, Cleveland, OH 44195-5283 and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH

G. M. Saidel

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH

S. C. Jones

Cerebrovascular Research Laboratory, The Cleveland Clinic Research Institute, 9500 Euclid Ave., Cleveland, OH 44195-5283

J Biomech Eng 117(1), 74-85 (Feb 01, 1995) (12 pages) doi:10.1115/1.2792273 History: Received January 24, 1993; Revised February 15, 1994; Online October 30, 2007


A thermal method has been developed to quantify continuous perfusion changes with self-calibration. A dynamic, one-dimensional bio-heat transfer model of the thermal probe and tissue describes the system response to either continuous or transient heating. A nonlinear least-squares fit of the model to experimental data yields estimates of the baseline perfusion and other model parameters. With a partial analytical solution of the model, the optimal estimation procedure is two orders of magnitude more efficient than with a total numerical solution of the model system. Experimental data is used to estimate the operating relations between perfusion and the temperature measurement. A new procedure has also been presented to obtain the dynamic response of the system for continuous measurement of perfusion.

Copyright © 1995 by The American Society of Mechanical Engineers
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