Preliminary Analysis of the Effects of Blood Vessel Movement on Blood Flow Patterns in the Coronary Arteries

[+] Author and Article Information
James E. Moore

Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, EPFL Champs—Courbes 1, 1024 Ecublens, Switzerland

Nicolas Guggenheim, Pierre-André Doriot, Pierre-André Dorsaz, Wilhelm Rutishauser

Cardiology Center, University Hospital, Geneva, Switzerland

Antonio Delfino

Biomedical Engineering Laboratory, Swiss Federal Institute of Technlogy

Jean-Jacques Meister

Biomedical Engineering Laboratory, Swiss Federal Institute of Technology

J Biomech Eng 116(3), 302-306 (Aug 01, 1994) (5 pages) doi:10.1115/1.2895734 History: Received March 05, 1993; Revised September 23, 1993; Online March 17, 2008


Blood flow patterns are believed to be involved in the formation and progression of arterial diseases. It is possible that the normal physiologic movement of blood vessels during the cardiac cycle affects blood flow patterns significantly. For example, the contraction of the heart in systole and subsequent relaxation in diastole create movements of the coronary arteries, as evidenced in real-time angiography. The effects of this movement on coronary artery flow patterns have never been previously analyzed. This work was undertaken to provide a preliminary estimate of the importance of the effects of such physiologic movements on blood flow patterns in the coronary arteries. A Womersley-type solution was used to determine the effect of axial movement on the wall shear rate in a simplified model of the coronary arteries. The pulsatile pressure gradient was derived from previously published coronary artery flow waveforms. The axial movement function was obtained from a three-dimensional reconstruction of a biplanar coronary angiogram. Significant changes in wall shear rate were noted when the movement was taken into account. The maximum and minimum wall shear rates were 10 percent smaller and 107 percent larger in magnitude respectively, and the Oscillatory Shear Index (OSI) was doubled. Most of the changes in wall shear rate were observed in systole, when the pressure gradient is minimal and the movement is strongest. The results indicate that blood vessel movement during the cardiac cycle has a significant effect on hemodynamic phenomena which have been associated with the development of atherosclerosis.

Copyright © 1994 by The American Society of Mechanical Engineers
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