Aortic Walls in Atherosclerotic Rabbits—Mechanical Study

[+] Author and Article Information
Kozaburo Hayashi

Department of Scientific Instrumentation and Control, Research Institute for Electronic Science, Hokkaido University, Sapporo 060, Japan; Department of Mechanical Engineering, Osaka University, Toyonaka, Osaka 560, Japan

Kazuhiro Ide

Health Science Research Laboratory, Matsushita Electric Works, Ltd., Kadoma, Osaka 571, Japan

Takeo Matsumoto

Department of Scientific Instrumentation and Control, Research Institute for Electronic Science, Hokkaido University, Sapporo 060, Japan

J Biomech Eng 116(3), 284-293 (Aug 01, 1994) (10 pages) doi:10.1115/1.2895732 History: Received January 06, 1992; Revised August 27, 1993; Online March 17, 2008


Mechanical properties of the descending thoracic aortae harvested from endothelial cell-denuded and/or cholesterol diet-fed rabbits were studied primarily with their pressure-diameter relationships. Male Japanese white rabbits having 3.1 to 3.5 kg initial body weight were divided into 4 groups. The rabbits in Groups A and C were fed a regular chow, while those in Groups B and D were given 1 percent cholesterol diet; the luminal surfaces of the descending thoracic aortae in the rabbits of Groups C and D were injured by drawing catheter-tip balloons. These animals were sacrificed after keeping for 4, 8, 16 or 32 weeks and, then, their descending thoracic aortae were excised for the studies of pressure-diameter relationships. Stiffness parameter (β′) and incremental elastic modulus (Hθθ were used to quantitatively represent the structural stiffness of the aortic wall and the elastic modulus of the wall material, respectively. Denudation of endothelial cells thickened the aortic walls in Group C, but induced no significant changes in β′ and Hθθ . Shape of the pressure-diameter curve changed gradually with time in Group D, and β′, Hθθ , and thickness to wall radius ratio increased significantly, while those in Group B showed no significant changes with a few exceptions. Averaged percent fraction of the luminal surface area stained with Sudan IV (As) was around 50 percent in Group B and 100 percent in Group D at 32 weeks. Even if As is over 80 percent in Group D, 50 percent (7/14) of the walls gave significantly higher β′- and Hθθ -values at 100 mm Hg than the others. Significantly increased calcification and intimal hyperplasia were observed in the walls with high β′- and Hθθ -values.

Copyright © 1994 by The American Society of Mechanical Engineers
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