A Numerical Analysis of a Focused Ultrasound Technique to Measure Perfusion

[+] Author and Article Information
Gary T. Anderson

Department of Electronics and Instrumentation, The University of Arkansas at Little Rock, Little Rock, AR 72202

Xiu Ye

Department of Mathematics and Statistics, The University of Arkansas at Little Rock, Little Rock, AR 72202

J Biomech Eng 116(2), 178-183 (May 01, 1994) (6 pages) doi:10.1115/1.2895717 History: Received April 29, 1992; Revised May 04, 1993; Online March 17, 2008


A noninvasive technique to measure perfusion using a focused ultrasound heating source and a thermistor placed on the surface of a tissue is proposed. The method is numerically examined in a model of the canine kidney. The perfusion measurement is shown to depend on several transducer and tissue thermal properties. A two level fractional factorial design simulation is used to map out a parameter value combination that maximizes the sensitivity of the measurement. A technique to numerically assess the uncertainty in the measurement due to uncertainties in the tissue and transducer parameter values is also described. The effects of the medulla and a subcapsular surface layer in the kidney are examined. It is determined that the maximum error in the measured perfusion rate due to all the factors considered is 17 percent for a kidney with a nominal perfusion rate of 300 mL/100g-min and a surface layer of 0.04 cm thickness.

Copyright © 1994 by The American Society of Mechanical Engineers
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