An Analysis of Coupled Multicomponent Diffusion in Interstitial Tissue

[+] Author and Article Information
P. D. Schreuders

University of Tennessee, Knoxville, Biology Division, Oak Ridge National Laboratory, P.O. Box 2009, Oak Ridge, Tennessee 37831-8077

K. R. Diller, J. J. Beaman

Biomedical Engineering Program, Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas 78712

H. M. Paynter

Adams Road RR1, Box 568, Pittsford, Vermont 05763

J Biomech Eng 116(2), 164-171 (May 01, 1994) (8 pages) doi:10.1115/1.2895715 History: Received June 09, 1989; Revised June 24, 1993; Online March 17, 2008


A one-dimensional multicomponent kinetic model was developed to simulate the interstitial diffusion of macromolecules in a three component system, consisting of water, the macromolecule and the interstitial matrix. Movement of the individual components was modeled as occurring in finite jumps between discrete low energy wells along paths defined in terms of species occupation. The flow rate was expressed as a function of the local species concentration, the jump distance, and a kinetic frequency parameter. The model, implemented in pseudo-bond graph form, was examined by fitting it to data obtained for the transport of fluorescein tagged dextran to determine the kinetic constants for that specific system.

Copyright © 1994 by The American Society of Mechanical Engineers
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