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RESEARCH PAPERS

The Effect of Laser Parameters on the Zone of Thermal Injury Produced by Laser Ablation of Biological Tissue

[+] Author and Article Information
V. Venugopalan

Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114-2600; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

N. S. Nishioka

Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114-2600

B. B. Mikić

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

J Biomech Eng 116(1), 62-70 (Feb 01, 1994) (9 pages) doi:10.1115/1.2895706 History: Received June 23, 1992; Revised February 12, 1993; Online March 17, 2008

Abstract

A thermal model to predict the effect of laser parameters on the zone of thermal injury produced by laser ablation of biological tissue is presented. The model suggests that the Péclèt number based on the optical penetration depth of laser radiation is the key parameter in determining the resulting zone of thermal injury. We show that the zone of thermal injury is minimized for Péclèt numbers greater than one since the transport of energy via conduction beyond the ablation front is minimized. We also show that for Péclèt numbers less than one, larger zones of thermal damage are unavoidable regardless of the laser pulse duration. The predictions of the model are compared with data available in the literature. Deviations between the model predictions and published data are discussed and the potential effects of the model assumptions, optical scattering, pyrolysis, temporal pulse shape, pulse duration, irradiance and pulse repetition rate are explored.

Copyright © 1994 by The American Society of Mechanical Engineers
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