Hemolytic Potential of Hydrodynamic Cavitation

[+] Author and Article Information
Sean D. Chambers

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48103e-mail: chambers@mc3corp.com

Robert H. Bartlett

Department of Surgery, University of Michigan, Ann Arbor, MI 48103

Steven L. Ceccio

Department of Mechanical Engineering and Applied Mechanics, University of Michigan, Ann Arbor, MI 48103

J Biomech Eng 122(4), 321-326 (Jan 05, 2000) (6 pages) doi:10.1115/1.1286560 History: Received September 03, 1998; Revised January 05, 2000
Copyright © 2000 by ASME
Your Session has timed out. Please sign back in to continue.


Brennen, C. E., 1995, Cavitation and Bubble Dynamics, Oxford University Press, New York.
Lamson,  T. C., Stinebring,  D. R., Deutsch,  S., Rosenberg,  G., and Tarbell,  J. M., 1991, “Real-Time In-Vitro Observation of Cavitation in a Prosthetic Heart Valve,” ASAIO J., 37, pp. M351–M353.
Graf,  T., Reul,  H., Detlefs,  C., Wilmes,  R., and Rau,  G., 1994, “Causes and Formation of Cavitation in Mechanical Heart Valves,” J. Heart Valve Dis., 3, pp. S49–S64.
Lee,  C. S., Chandran,  K. B., and Chen,  L. D., 1996, “Cavitation Dynamics of Medtronic Hall Mechanical Heart Valve Prosthesis: Fluid Squeezing Effect,” ASME J. Biomech. Eng., 118, pp. 97–105.
Hwang,  N. H. C., 1998, “Cavitation Potential of Pyrolytic Carbon Heart Valve Prostheses: A Review and Current Status,” J. Heart Valve Dis., 7, pp. 140–150.
Lamson,  T. C., Rosenberg,  G., Geselowitz,  D. B., Deutsch,  S., Stinebring,  D. R., Frangos,  J. A., and Tarbell,  J. M., 1993, “Relative Blood Damage in the Three Phases of a Prosthetic Heart Valve Flow Cycle,” ASAIO J., 39, pp. M626–M633.
Garrison,  L. A., Lamson,  T. C., Deutsch,  S., Geselowitz,  D. B., Gaumond,  R. P., and Tarbell,  J. M., 1994, “An In-Vitro Investigation of Prosthetic Heart Valve Cavitation in Blood,” J. Heart Valve Dis., 3, pp. S8–S24.
Bluestein,  M., and Mockros,  L. F., 1968, “Hemolytic Effects of Energy Dissipation in Flowing Blood,” Med. Biol. Eng., 7, pp. 1–16.
Freed,  D., Walker,  W. F., Dube,  C. M., and Tokuno,  T., 1981, “Effects of Vaporous Cavitation Near Prosthetic Surfaces,” Trans. Am. Soc. Artif. Intern. Organs, 27, pp. 105–109.
Chambers,  S. D., Laberteaux,  K. R., Merz,  S. I., Montoya,  J. P., and Bartlett,  R. H., 1996, “Effects of Static Pressure on Red Blood Cells on Removal of the Air Interface,” ASAIO J., 42, pp. 947–950.
Williams, A. R., 1983, Ultrasound: Biological Effects and Potential Hazards, Academic Press, New York.
Miller,  D. L., 1988, “The Influence of Hematocrit on Hemolysis by Ultrasonically Activated Gas-Filled Micropores,” Ultrasound Med. Biol., 14, pp. 293–297.
Church,  C. C., and Miller,  M. W., 1983, “The Kinetics and Mechanics of Ultrasonically-Induced Cell Lysis Produced by Non-trapped Bubbles in a Rotating Culture Tube,” Ultrasound Med. Biol., 9, pp. 385–393
Yang, W.-J., 1974, “A Major Cause of Blood Trauma in Extracorporeal Circulation,” ASME Adv. Bioeng., pp. 167–168.
Fung, Y.-C., 1990, Biomechanics: Motion, Flow, Stress, and Growth, Springer-Verlag, New York.
Chambers, S. D., 1998, “Examination of the Effects of Subatmospheric Pressure on Erythrocytes and the Inception of Cavitation in Blood,” Ph.D. Thesis, University of Michigan, Ann Arbor, MI.
Chambers,  S. D., Bartlett,  R. H., and Ceccio,  S. L., 1999, “Determination of the In Vivo Cavitation Nuclei Characteristics of Blood,” ASAIO J., 45, pp. 541–549.
Ceccio, S. L., Gowing, S., and Gindroz, B., 1995, “A Comparison of CSM Bubble Detection Methods.” Proc. ASME Symposium on Cavitation and Gas–Liquid Flow in Fluid Machinery and Devices, pp. 43–49.
Yang, W.-J., 1989, Biothermal Fluid Thermal Sciences, Hemisphere Publishing, New York.
Walder,  D. N., 1948, “Serum Surface Tension and its Relation to the Decompression Sickness of Aviators,” J. Physiol. (Lond), 548, pp. 48P–49P.
Ragone, D. V., 1995, Thermodynamics of Materials, I , Wiley, New York.
Li,  X. Z., Barthes-Biesel,  D., and Helmy,  A., 1988, “Large Deformations and Burst of a Capsule Freely Suspended in an Elongational Flow,” J. Fluid Mech., 187, pp. 179–196.
Pozrikidis,  C., 1990, “The Axisymmetric Deformation of a Red Blood Cell in Uniaxial Straining Stokes Flow,” J. Fluid Mech., 216, pp. 231–254.
Chambers,  S. D., Ceccio,  S. L., Annich,  G. A., and Bartlett,  R. H., 1999, “Extreme Negative Pressure does not Cause Erythrocyte Damage in Flowing Blood,” ASAIO J., 45, pp. 431–435.
Sanderson, J. H., and Phillips, C. E., 1981, An Atlas of Laboratory Animal Haematology, Clarendon Press, Oxford.
Plesset,  M. S., and Prosperetti,  A., 1977, “Bubble Dynamics and Cavitation,” Annu. Rev. Fluid Mech., 9, pp. 145–185.
d’Agostino,  L., and Acosta,  A. J., 1991, “Separation and Surface Nuclei Effects in a Cavitation Susceptibility Meter,” ASME J. Fluids Eng., 113, pp. 695–699.
Sallam,  A. M., and Hwang,  N. C., 1984, “Human Red Cell Hemolysis in a Turbulent Jet Shear Flow: Contribution of Reynolds Shear Stresses,” Biorheology, 21, pp. 783–797.
Tassin-Leger,  A., and Ceccio,  S. L., 1998, “Examination of the Flow Near the Leading Edge of Attached Cavitation: Part I—Detachment of Two-Dimensional and Axisymmetric Cavities,” J. Fluid Mech., 376, pp. 61–90.


Grahic Jump Location
Schematic of the single-pass experimental apparatus: Cavitation Susceptibility Meter (CSM), syringe pump (SP), differential pressure transducer (DPT), gage pressure transducer (GPT), three-way ball valve for priming apparatus (BV), collection chamber (CC), pressure vessel (PV), vacuum source (VS), acoustic counter (AC).
Grahic Jump Location
Mechanical drawing of the Cavitation Susceptibility Meter (CSM) with units in millimeters. The CSM was constructed by an electroplating technique. The inner surface is gold and the structure is copper.
Grahic Jump Location
Schematic of the recirculating flow apparatus: bubble trap (BT), centrifugal pump (CP), Cavitation Susceptibility Meter (CSM), acoustic counter (AC), differential pressure transducer (DPT), gage pressure transducer (GPT), heat exchanger (HE).
Grahic Jump Location
Comparison of the measured inlet pressure (Pin) to the calculated inlet pressure (P(0)) by the computational fluid dynamic (CFD) simulation (open square, Pin; closed triangle, P(0)). The fluid is bovine blood with a viscosity of 0.0047 kg/m-s (4.7 cP). The error bars are standard deviation with N≥3.*N=1.
Grahic Jump Location
Predicted plasma-free hemoglobin released by a single cavitation event per ml of plasma (PFHbs) for cavitation bubbles of varying initial radius. The lysis criterion was 105 s−1. The pressure profile, P(τ), was taken from the computational fluid dynamics simulation with Vin=0.73 m/s and Po=−23 kPa (−170 mmHg).
Grahic Jump Location
Rate of plasma-free hemoglobin (PFHb) generation versus Cavitation Number (σ) for the recirculating flow experiment. Circuit flow rate was constant at 2.8 L/min with the free-stream pressure varied to vary σ. The blood was freshly collected from bovine. The error bars are standard deviation with N=3.
Grahic Jump Location
Rate of plasma-free hemoglobin (PFHb) generation versus Cavitation Number (σ) for the recirculating flow experiments (open square, freshly collected bovine blood; closed square, two-day-old bovine blood). Circuit flow rate was constant at 3 L/min with the free-stream pressure varied to vary σ and N=1.




Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In