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TECHNICAL PAPERS

Observation and Quantification of Gas Bubble Formation on a Mechanical Heart Valve

[+] Author and Article Information
Hsin-Yi Lin, Brian A. Bianccucci, J. M. Tarbell

Bioengineering Department, Penn State University, University Park, PA 16802-4400

Steven Deutsch, Arnold A. Fontaine

Applied Research Laboratory, Penn State University, University Park, PA 16802-4400

J Biomech Eng 122(4), 304-309 (Mar 22, 2000) (6 pages) doi:10.1115/1.1287171 History: Received September 22, 1999; Revised March 22, 2000
Copyright © 2000 by ASME
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References

Grosset,  D. G., Georgiadis,  D., Kelman,  A. W., and Lees,  K. R., 1993, “Quantification of Ultrasound Emboli Signals in Patients With Cardiac and Carotid Disease,” Stroke, 24, pp. 1922–1924.
Eftedal,  O., and Brubakk,  A., 1993, “Detecting Intravascular Bubbles in Ultrasonic Images,” Med. Biol. Eng. Comput., 31, pp. 627–633.
Reisner,  S., Rinkevich,  D., Markiewicz,  W., Adler,  Z., and Milo,  S., 1992, “Spontaneous Echocardiographic Contrast With the Carbomedics Mitral Valve Prosthesis,” Am. J. Cardiol., 70, pp. 1497–1500.
Orsinelli,  D., Pasierski,  T., and Pearson,  A., 1994, “Spontaneously Appearing Microbubbles Associated With Prosthetic Cardiac Valves Detected by Transophagael Echocardiography,” Am. Heart J., 128, No. 5, pp. 990–996.
Brakken,  S., Russel,  D., Brucher,  R., and Svennevig,  J., 1995, “Incidence and Frequency of Cerebral Embolic Signals in Patients in a Similar Bileaflet Mechanical Heart Valves,” Stroke, 27, No. 7, pp. 1225–1230.
Dauzat,  M., Deklunder,  G., Aldis,  A., Robinovitch,  M., Burte,  F., and Bret,  P., 1994, “Gas Bubble Emboli Detected by Transcranial Doppler Sonography in Patients With Prosthetic Heart Valves: A Preliminary Report,” J. Ultrasound Med., 13, pp. 129–135.
Georgiadis,  D., Grosset,  D., Kelman,  A., Faichney,  A., and Lees,  K., 1994, “Prevalence and Characteristics of Intracranial Microemboli Signals in Patients With Different Types of Prosthetic Cardiac Valves,” Stroke, 25, No. 3, pp. 587–592.
Biancucci,  B., Deutsch,  S., Geselowitz,  D. B., and Tarbell,  J. M., 1999, “In Vitro Studies of Gas Bubble Formation by Mechanical Heart Valves,” J. Heart Valve Dis., 8, pp. 186–196.
Anderson,  R. M., Ritz,  J. M., and O’Hare,  J. G., 1965, “Pulmonary Air Emboli During Cardiac Surgery,” J. Thorac. Cardiovasc. Surg., 49, pp. 440–449.
Heppner,  F., 1952, “Air Embolism Eight Hours After Ventriculography,” Acta Radiol., 38, pp. 294–298.
Nicols,  H. T., Morse,  D. R., and Hirose,  T., 1958, “Coronary and Other Air Embolism Occurring During Open-Heart Surgery,” Surgery, 43, pp. 236–244.
Starr,  A., 1960, “The Mechanism and Prevention of Air Embolus During Correction of Congenital Cleft Nutral Valve,” J. Thorac. Cardiovasc. Surg., 39, pp. 808–814.
Hill, L., and Greenwood, M., 1910, “On the Formation of Bubbles in the Vessels of Animal Submitted to a Partial Vacuum,” J. Physiol. 39 , p. xxii.
Harris,  M., Berg,  W. E., Whitaker,  D. M., and Twitty,  V. C., 1945, “The Relation of Exercise to Bubble Formation in Animals Decompressed to Sea Level From High Parametric Pressure,” J. Gen. Physiol., 28, pp. 241–251.
Harvey,  Z. N., 1945, “Decompression Sickness and Bubble Formation in Blood and Tissues,” Acad. Med., Bull. NY, 21, pp. 205–536.
Yang,  W., and Chan,  K., 1969, “Survey of Literature Related to the Problems of Gas Embolism in Human Body,” J. Biomech., 2, pp. 299–312.
Elliot, D., and Hallenbeck, J., 1975, “The Pathophysiology of Decompression Sickness,” in: Physiology and Medicine of Diving, 2nd ed., Chap. 23, Bennet, P., ed., London, Bailliere Tindall.
Moore,  R. M., and Braselton,  C. W., 1940, “Injection of Air and of Carbon Dioxide Into Pulmonary Vein,” Ann. Surg., 112, pp. 212–218.
Nun,  J., 1959, Letter to Editor, Anesthesia, 14, p. 413.
Munson,  E. S., and Merrich,  H. C., 1966, “Effects of Nitrous Oxide on Venous Air Embolism,” Anesthesiology, 27, pp. 783–787.
Lamson,  T., Stinebring,  D., Deutsch,  S., Rosenberg,  G., and Tarbell,  J., 1991, “Real Time in Vitro Observation of Cavitation in a Prosthetic Heart Valve,” ASAIO Trans., 37, pp. M351–M353.
Graf,  T., Fischer,  H., Detlefs,  C., Wilmes,  R., and Rau,  G., 1991, “Cavitation Potential of Mechanical Heart Prostheses,” Int. J. Artif. Organs, 14, pp. 169–174.
Chandran,  K. B., Lee,  C. S., and Chen,  L. D., 1994, “Pressure Field in the Vicinity of Mechanical Valve Occluders at the Instant of Valve Closure: Correlation With Cavitation Initiation,” J. Heart Valve Dis., (Suppl. I), 3, pp. S65–S86.
Garrison, L., 1994, “Hemolytic Effects of Chemical Additives, Aortic Pressure Changes, and Cavitation in Two New Mock Circulatory Loops Driven by the Penn State Ventricular Assist Device,” Ph.D. thesis, Bioengineering, The Pennsylvania State University, University Park, PA.
Garrison,  L., Lamson,  T., Deutsch,  S., Geselowitz,  D., Gaumond,  R., and Tarbell,  J., 1994, “An In-Vitro Investigation of Prosthetic Heart Valve Cavitation in Blood,” J. Heart Valve Dis., 3, pp. S8–S24.
Zapanta,  C., Liszka,  E., Lamson,  T., Stinebring,  D., Deutsch,  S., Geselowitz,  D., and Tarbell,  J., 1994, “A Method for Real-Time in Vitro Observation of Cavitation on Prosthetic Heart Valves,” ASME J. Biomech. Eng., 116, pp. 450–468.
Wu,  Z. J., Gao,  B. Z., and Hwang,  H. H. C., 1995, “Transient Pressure at Closing of a Monoleaflet Mechanical Heart Valve Prosthesis: Mounting Compliance Effect,” J. Heart Valve Dis., 4, pp. 553–567.
Sneckenberger,  D. S., Stinebring,  D. R., Deutsch,  S., Geselowitz,  D. B., and Tarbell,  J. M., 1996, “Mitral Health Valve Cavitation in an Artificial Heart Environment,” J. Heart Valve Dis., 5, pp. 216–227.
Zapanta,  C. M., Stinebring,  D. R., Deutsch,  S., Geselowitz,  D. B., and Tarbell,  J. M., 1998, “A Comparison of the Cavitation Potential of Prosthetic Heart Valves Based on Valve Closing Dynamics,” J. Heart Valve Dis., 7, No. 6, pp. 655–667.
Kafesjian,  R., Howanec,  R., Ward,  G. D., Diep,  L., Wagstaff,  L. S., and Rhee,  R., 1994, “Cavitation Damage of Pyrolytic Carbon in Mechanical Heart Valves,” J. Heart Valve Dis. (Suppl. 1), 3, pp. S2–S7.
Young, F. R., 1989, Cavitation, McGraw-Hill, New York.
Altmann, P., and Dittmer, S., 1971, Respiration and Circulation, Federation of American Societies for Experimental Biology, Bethesda, MD.
Georgiadis,  D., Wenzel,  A., Lehmann,  D., Lindner,  A., Zerkowski,  H. R., Ziera,  S., and Spencer,  M. P., 1997, “Influence of Oxygen Ventilation on Doppler Microemboli Signals in Patients With Artificial Heart Valves,” Stroke, 28, pp. 2189–2194.
Droste,  D. W., Hansberg,  T., Kemeny,  V., Hammel,  D., Schulte-Altedorneburg,  G., Nabavi,  D. G., Kaps,  M., Scheld,  H. H., and Ringelstein,  E. B., 1997, “Oxygen Inhalation Can Differentiate Gaseous From Nongaseous Microemboli Detected by Transcranial Doppler Ultrasound,” Stroke, 28, No. 12, pp. 2453–2456.

Figures

Grahic Jump Location
Schematic diagram of the mock circulatory flow loop
Grahic Jump Location
An example of the before (top) and after (bottom) band-pass-filtering pressure trace and its power spectrum; Crms=19.5 mmHg in this case
Grahic Jump Location
Schematic of the videographic system for visualizing the mitral valve and ultrasonic detection of bubbles in the aortic outlet
Grahic Jump Location
A series of images showing the mechanism by which nuclei were generated after the cavitation vapor condensed back into the solution under conditions of high Crms and high PCO2: (a) cavitation at the edge of the occluder and around the central strut (0.986 ms); (b) nucleus cloud left behind after the collapse of vortex cavitation (4.930 ms); (c) due to the diffusion of CO2 into the nuclei, bubbles became larger (5.914 ms)
Grahic Jump Location
Schematic of the mechanism of gas bubble formation: (a) cavitation; (b) enlarged gas nuclei being carried away immediately after cavitation collapse; (c) gas bubbles generated later on the valve surface; (d) nuclei that remained on the valve surface grew larger due to gas diffusion or coalescence; (e) gas bubbles swept from the surface when the valve reopened
Grahic Jump Location
(a) Plots of gray level (G.L.) versus PCO2 at different Crms; (b) G.L. versus Crms at different PCO2. Error bars represent 95 percent confidence intervals.
Grahic Jump Location
Ultrasound images at different operating conditions: (a) high Crms and low PCO2; G.L.=786; (b) medium Crms and high PCO2; G.L.=1064; (c) high Crms and high PCO2; G.L.=1551. D is the estimated bubble diameter.

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