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TECHNICAL BRIEFS

Mechanical Properties of a Biodegradable Bone Regeneration Scaffold

[+] Author and Article Information
B. D. Porter, J. B. Oldham, S.-L. He, M. E. Zobitz, K. N. An, B. L. Currier

Departments of Orthopedic Surgery and Bioengineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905

R. G. Payne, A. G. Mikos, M. J. Yaszemski

Department of Bioengineering, Institute of Biosciences and Bioengineering, Rice University, Houston, TX 77005

J Biomech Eng 122(3), 286-288 (Feb 06, 2000) (3 pages) doi:10.1115/1.429659 History: Received October 31, 1999; Revised February 06, 2000
Copyright © 2000 by ASME
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References

Vacanti,  C. A., Kim,  W., Upton,  J., Vacanti,  M. P., Mooney,  D., Schloo,  B., and Vacanti,  J. P., 1993, “Tissue-Engineered Growth of Bone and Cartilage,” Transplant. Proc., 25, pp. 1019–1021.
Gazdag,  A. R., Lane,  J. M., Glaser,  D., and Forster,  R. A., 1995, “Alternatives to Autogenous Bone Graft: Efficacy and Indications,” J. Am. Acad. Orthop. Surg., 3, pp. 1–8.
Peter,  S. J., Miller,  T. T., Zhu,  G., Yasko,  A. W., and Mikos,  A. G., 1998, “In Vivo Degradation of a Poly(Propylene Fumarate)/β-Tricalcium Phosphate Injectable Composite Scaffold,” J. Biomed. Mater. Res., 41, pp. 1–7.
Peter,  S. J., Suggs,  L. J., Yaszemski,  M. J., Engel,  P. S., and Mikos,  A. G., 1999, “Synthesis of Poly(Propylene Fumarate) by Acylation of Propylene Glycol in the Presence of a Proton Scavenger,” J. Biomater. Sci., Polym. Ed., 10, pp. 363–373.
Piecuch,  J. F., 1992, “Extraskeletal Implantation of a Porous Hydroxyapatite Ceramic,” J. Dent. Res., 61, pp. 1458–1460.
Keller,  T. S., Mao,  Z., and Spengler,  D. M., 1990, “Young’s Modulus, Bending Strength, and Tissue Physical Properties of Human Compact Bone,” J. Orthop. Res., 8, pp. 592–603.
Yaszemski,  M. J., Payne,  R. G., Hayes,  W. C., Langer,  R., and Mikos,  A. G., 1996, “In Vitro Degradation of a Poly(Propylene Fumarate)-Based Composite Material,” Biomaterials, 17, pp. 2127–2130.

Figures

Grahic Jump Location
Representative force versus displacement curves for the bending testing (group 1)
Grahic Jump Location
Bending strength and compressive strength with different β-TCP and porogen contents
Grahic Jump Location
Modulus of elasticity in bending and compression with different β-TCP and porogen contents

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