A Novel Injectable Collagen Matrix: In Vitro Characterization and In Vivo Evaluation

[+] Author and Article Information
Damien Laude, Kevin Odlum, Stewart Rudnicki, Nathaniel Bachrach

Organogenesis, Inc., 150 Dan Rd., Canton, MA 02021

J Biomech Eng 122(3), 231-235 (Feb 06, 2000) (5 pages) doi:10.1115/1.429653 History: Received October 21, 1999; Revised February 06, 2000
Copyright © 2000 by ASME
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The macrostructural strands of the ECF formulations are shown here prepared on a glass slide for image analysis for both the short thin strands (ST) and the long wide strands (LW). Note the distinct nature of the strands between formulations and the uniformity within each group of strands.
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The permeability (a) and confined compression (b) testing devices shown in schematic form
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The injectability of ECF is dependent its concentration and the needle gage used. The (*) on each main variable indicates that it has a significant effect (p<0.05, ANOVA). In both variables each level was found to be significantly different from the other two (p<0.05, N-K post hoc analysis). There was also a significant interaction found between the effect of needle gage and ECF concentration.
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The permeability of ECF formulations was determined as a function of concentration of the ECF strands. Both short thin (ST) and long wide (LW) strand formulations of ECF reach a concentration at which permeability is measurable and beyond which the permeability decreases in a nonlinear fashion.
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The ECF formulations were tested in confined compression in a three-stage experiment. The creep response for each stage was then fit empirically to a simple model. Typical experimental strain-time curves are shown for the low load (a), high load (b), and recovery (c) along with their respective curve fits.
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This figure shows the in vivo persistence of the ECF formulations injected subcutaneously into rabbit ears for both; (a) the short-term mechanical compaction over a 72 hour period and (b) the long-term stability of the short thin (ST) and long wide (LW) strand ECF formulations for 330 days




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