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RESEARCH PAPERS

A Numerical Simulation of Flow in a Two-Dimensional End-to-Side Anastomosis Model

[+] Author and Article Information
D. A. Steinman

Department of Mechanical Engineering, University of Toronto, Toronto, Canada

Bach Vinh, C. Ross Ethier

Department of Mechanical Engineering and Institute for Biomedical Engineering, University of Toronto, Toronto, Canada

M. Ojha, R. S. C. Cobbold, K. W. Johnston

Institute for Biomedical Engineering, University of Toronto, Toronto, Canada

J Biomech Eng 115(1), 112-118 (Feb 01, 1993) (7 pages) doi:10.1115/1.2895457 History: Received July 24, 1991; Revised May 02, 1992; Online March 17, 2008

Abstract

In order to understand the possible role that hemodynamic factors may play in the pathogenesis of distal anastomotic intimal hyperplasia, we carried out numerical simulations of the flow field within a two-dimensional 45 degree rigid-walled end-to-side model anastomosis. The numerical code was tested and compared with experimental (photochromic dye tracer) studies using steady and near-sinusoidal waveforms, and agreement was generally very good. Using a normal human superficial femoral artery waveform, numerical simulations indicated elevated instantaneous wall shear stress magnitudes at the toe and heel of the graft-host junction and along the host artery bed. These sites also experienced highly variable wall shear stress behavior over the cardiac cycle, as well as elevated spatial gradients of wall shear stress. These observations provide additional evidence that intimal hyperplasia may be correlated to wall shear stresses over the cardiac cycle, high wall shear stress gradients, or a combination of the three. The limitations of the present work (especially in regard to the two-dimensional nature of the flow simulations) are discussed, and results are compared to previous observations about distal anastomotic intimal hyperplasia.

Copyright © 1993 by The American Society of Mechanical Engineers
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