An Experimental Model of Gas Dispersion and Uptake at the Bronchial Wall

[+] Author and Article Information
S. R. Kaye, R. C. Schroter

Physiological Flow Studies Unit, Centre for Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London SW7 2BY, England

J Biomech Eng 115(1), 91-96 (Feb 01, 1993) (6 pages) doi:10.1115/1.2895475 History: Received October 01, 1991; Revised April 23, 1992; Online March 17, 2008


Dispersion and uptake of gas boli of a range of solubilities was examined in lung airway models; first a straight tube, then a four generation network. Airway liquid lining was simulated with gelatin. The bolus dispersion was determined from the first three moments of the concentration profile measured at two positions downstream. The disruption of the flow by the bifurcations significantly reduces the dispersion of an insoluble gas, compared to that predicted in an equivalent network of parallel straight tubes. Retention of gas in the wall increases with solubility causing increased bolus dispersion and decreased average speed. For highly soluble gases this process dominates and the effect of bifurcations becomes less significant.

Copyright © 1993 by The American Society of Mechanical Engineers
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