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RESEARCH PAPERS: Papers on Hemodynamics and the Arterial Wall

The Distribution of Fluid Forces on Model Arterial Endothelium Using Computational Fluid Dynamics

[+] Author and Article Information
R. L. Satcher, S. R. Bussolari, C. F. Dewey

Fluid Mechanics Laboratory, Department of Mechanical Engineering, M.I.T., Cambridge, MA 02130

M. A. Gimbrone

Vascular Research Division, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115

J Biomech Eng 114(3), 309-316 (Aug 01, 1992) (8 pages) doi:10.1115/1.2891388 History: Received November 08, 1991; Revised February 28, 1992; Online March 17, 2008

Abstract

Numerical calculations are used in conjunction with linear perturbation theory to analyze the problem of laminar flow of an incompressible fluid over a wavy surface which approximates a monolayer of vascular endothelial cells. These calculations model flow conditions in an artery very near the vessel wall at any instant in time, providing a description of the velocity field with detail that would be difficult to identify experimentally. The surface pressure and shear stress distributions are qualitatively similar for linear theory and numerical computations. However, the results diverge as the amplitude of surface undulation is increased. The shear stress gradient along the cell model surface is reduced for geometries which correspond to aligned endothelial cells (versus nonaligned geometries).

Copyright © 1992 by The American Society of Mechanical Engineers
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