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RESEARCH PAPERS: Papers on Hemodynamics and the Arterial Wall

Endothelial Cell Morphometry of Atherosclerotic Lesions and Flow Profiles at Aortic Bifurcations in Cholesterol Fed Rabbits

[+] Author and Article Information
Mitsuji Okano, Yoji Yoshida

Yamanashi Medical College, Nakakoma, Yamanashi, Japan 409-38

J Biomech Eng 114(3), 301-308 (Aug 01, 1992) (8 pages) doi:10.1115/1.2891387 History: Received August 15, 1991; Revised February 07, 1992; Online March 17, 2008

Abstract

Observations on shapes of endothelial cells both in sudanophilic and nonsudanophilic regions at bifurcations of the brachiocephalic (BC) and left subclavian (SA) arteries in hyperlipidemic rabbits were performed under a SEM. The stagnation point of flow and leading edges of flow dividers were nonsudanophilic and covered by round and long fusiform endothelial cells, respectively. The hips of flow dividers of both branchings, proven to be relatively low shear stress regions, by movement of microspheres in steady flow, were sudanophilic and covered by ellipsoidal cells. Similar studies were carried out in normolipidemic rabbits. It might be concluded that lipid deposition in hyperlipidemic rabbits occurs in relatively low shear stress regions, where endothelial cells are functionally activated, rather than in laminar high shear stress regions at the flow divider.

Copyright © 1992 by The American Society of Mechanical Engineers
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