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RESEARCH PAPERS: Papers on Tissue Engineering

Candidates for the Mechanosensory System in Bone

[+] Author and Article Information
S. C. Cowin

Department of Mechanical Engineering, The City College of The City University of New York, New York, NY 10031

L. Moss-Salentijn, M. L. Moss

Division of Orofacial Development, Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032

J Biomech Eng 113(2), 191-197 (May 01, 1991) (7 pages) doi:10.1115/1.2891234 History: Received January 20, 1991; Revised February 01, 1991; Online March 17, 2008

Abstract

Some potential mechanisms by which bone cells sense mechanical loads are described and hypotheses concerning the functioning of these mechanisms are explored. It is well known that bone tissue adapts its structure to its mechanical load environment. Recent research has illuminated the biological response of bone to mechanical loading at the cellular level, but the precise mechanosensory system that signals bone cells to deposit or resorb tissue has not been identifed. The purpose of this paper is to describe the current status of this research and to suggest some possible mechanosensory systems by which bone cells might sense environmental loads.

Copyright © 1991 by The American Society of Mechanical Engineers
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