RESEARCH PAPERS: Papers on Tissue Engineering

Bioengineering in Development of the Hybrid Artificial Pancreas

[+] Author and Article Information
C. K. Colton, E. S. Avgoustiniatos

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

J Biomech Eng 113(2), 152-170 (May 01, 1991) (19 pages) doi:10.1115/1.2891229 History: Received February 12, 1991; Revised February 12, 1991; Online March 17, 2008


The hybrid artificial pancreas for treatment of diabetes consists of insulin-secreting pancreatic tissue which is surrounded by a membrane that protects the tissue from rejection by the immune system following implantation. In this paper, we review the alternative therapeutic approaches for diabetes under study and then discuss the technical requirements that must be met by a hybrid device useful to humans. Previous work on intravascular and extravascular immunoisolation devices is reviewed from the standpoint of these requirements, and three critical unresolved issues are discussed: biocompatibility, oxygen supply limitations, and prevention of immune rejection.

Copyright © 1991 by The American Society of Mechanical Engineers
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