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RESEARCH PAPERS

Relationship Between Mechanical Properties and Collagen Structure of Closed and Open Wounds

[+] Author and Article Information
Charles J. Doillon, Michael G. Dunn, Frederick H. Silver

Biomaterials Center and Graduate Program in Biomedical Engineering, Department of Pathology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854

J Biomech Eng 110(4), 352-356 (Nov 01, 1988) (5 pages) doi:10.1115/1.3108453 History: Received August 26, 1987; Revised July 24, 1988; Online June 12, 2009

Abstract

Mechanical properties and collagen structure of excisional wounds left open are compared with wounds closed by clips. In both wound models, collagen fiber diameter increases with time post-wounding and is related to tensile strength. Clipped wounds show a higher ultimate tensile strength and tangent modulus compared with open wounds. In clipped wounds, newly deposited collagen appears as a biaxially oriented network as observed in normal skin. In open wounds a delay in the organization of the collagen network is observed and parallel wavy-shaped ribbons of collagen fibers are deposited. At long term, the high extensibility observed in open wounds may be due to the sliding of ribbons of collagen fibers past each other.

Copyright © 1988 by ASME
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