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RESEARCH PAPERS

The Effects of RPM and Recycle on Separation Efficiency in a Clinical Blood Cell Centrifuge

[+] Author and Article Information
P. D. Drumheller, B. J. Van Wie, J. N. Petersen, R. J. Oxford

Chemical Engineering Department, Washington State University, Pullman, WA 99164-2710

G. W. Schneider

Spokane & Inland Empire Blood Bank, Spokane, WA 99207

J Biomech Eng 109(4), 324-329 (Nov 01, 1987) (6 pages) doi:10.1115/1.3138688 History: Received July 01, 1987; Revised September 29, 1987; Online June 12, 2009

Abstract

A COBE blood cell centrifuge, model 2997 with a single stage channel, was modified to allow computer controlled sampling, and to allow recycle of red blood cells (RBCs) and plasma streams using bovine whole blood. The effects of recycle of the packed RBC and plasma product streams, and of the centrifuge RPM on platelet and white blood cell (WBC) separation efficiencies were quantified using a central composite factorial experimental design. These data were then fit using second order models. Both the model for the WBC separation efficiency and the model for the platelet separation efficiency predict that RPM has the greatest effect on separation efficiency and that RBC and plasma recycle have detrimental effects at moderate to low RPM, but have negligible impact on separation efficiency at high RPM.

Copyright © 1987 by ASME
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