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RESEARCH PAPERS

Intramyocardial Pressure and Coronary Extravascular Resistance

[+] Author and Article Information
P. D. Stein, H. N. Sabbah

Department of Medicine, Division of Cardiovascular Medicine, and Department of Surgery, Henry Ford Hospital, Detroit, Mich. 48202

M. Marzilli

Institute of Clinical Physiology, Pisa, Italy

J Biomech Eng 107(1), 46-50 (Feb 01, 1985) (5 pages) doi:10.1115/1.3138519 History: Received September 18, 1983; Revised February 10, 1984; Online June 15, 2009

Abstract

Intramyocardial pressure is an indicator of coronary extravascular resistance. During systole, pressure in the subendocardium exceeds left ventricular intracavitary pressure; whereas pressure in the subepicardium is lower than left ventricular intracavitary pressure. Conversely, during diastole, subepicardial pressure exceeds both subendocardial pressure and left ventricular pressure. These observations suggest that coronary flow during systole is possible only in the subepicardial layers. During diastole, however, a greater driving pressure is available for perfusion of the subendocardial layers relative to the subepicardial layers. On this basis, measurements of intramyocardial pressure contribute to an understanding of the mechanisms of regulation of the phasic and transmural distribution of coronary blood flow.

Copyright © 1985 by ASME
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