Effects of Fluid Flow on Living Vascular Cells

[+] Author and Article Information
C. F. Dewey

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Mass. 02139

J Biomech Eng 106(1), 31-35 (Feb 01, 1984) (5 pages) doi:10.1115/1.3138453 History: Received April 10, 1983; Revised October 19, 1983; Online June 15, 2009


Shear stress produced by a flowing fluid has been found to cause changes in the structure and function of vascular endothelial cells. They tend to become elongated and aligned with the direction of flow. They respond to changes in fluid shear stress (either from low shear to high shear or vice versa) by transiently increasing fluidphase endocytosis. And they are capable of producing intracellular actin and myosin filaments that are oriented in the flow direction.

Copyright © 1984 by ASME
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