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TECHNICAL BRIEFS

The Effect of Incomplete Fixation of Elastin on the Appearance of Pulmonary Alveoli

[+] Author and Article Information
S. S. Sobin

American Heart Association/Greater Los Angeles Affiliate, University of Southern California, California Cardiovascular Research Laboratory, Los Angeles, Calif. 90033; Department of Applied Mechanics and Engineering Sciences/Bioengineering, University of California, San Diego, La Jolla, Calif. 92093

Y.-C. B. Fung

Department of Applied Mechanics and Engineering Sciences/Bioengineering, University of California, San Diego, La Jolla, Calif. 92093

H. M. Tremer

American Heart Association/Greater Los Angeles Affiliate, University of Southern California, California Cardiovascular Research Laboratory, Los Angeles, Calif. 90033

J Biomech Eng 104(1), 68-71 (Feb 01, 1982) (4 pages) doi:10.1115/1.3138307 History: Received November 09, 1981; Online June 15, 2009

Abstract

Pulmonary alveolar geometry in histological sections prepared by quick-freezing the lung, with freeze-substitution of ice, fixation of the dry lung with osmium tetroxide in nonaqueous and nonpolar solvent and celloidin embedding is remarkably different from the geometry seen in preparations made by instilling aqueous aldehyde or osmium tetroxide solution in the airways. The alveolar walls in the quick-frozen lung are linear; those in the others are wrinkled. The difference was demonstrated to be due to incomplete fixation of elastin.

Copyright © 1982 by ASME
Topics: Freezing , Ice , Geometry , Lung
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