Correlation of Human Arterial Morphology With Hemodynamic Measurements in Arterial Casts

[+] Author and Article Information
M. H. Friedman, G. M. Hutchins, C. B. Bargeron, O. J. Deters, F. F. Mark

The Johns Hopkins University, Applied Physics Laboratory, Laurel, Md. and School of Medicine, Baltimore, Md.

J Biomech Eng 103(3), 204-207 (Aug 01, 1981) (4 pages) doi:10.1115/1.3138279 History: Received June 15, 1981; Online June 15, 2009


A realistic pulsatile flow was passed through a cast of the aortic bifurcation of a 63-yr-old male with mild atherosclerosis, and a laser Doppler anemometer was used to measure fluid velocities in the cast at 15 selected sites near the lateral and medial walls. Intimal, medial and adventitial thicknesses were measured and sudanophilia was scored at corresponding sites in the vessel from which the cast had been made. A negative correlation was found between intimal thickness (IT) and wall shear rate. The strongest negative correlation (p<0.005) was between IT and “pulse shear rate” (PSR), defined by analogy with pulse pressure. Sudanophilia also correlated negatively with PSR (p<0.01). Medial thickness correlated positively with shear rate, and most strongly with the mean (i.e., time-average) rate (p<0.005). From an analysis of the fluid mechanical data, it appears possible to separate the effects of bifurcation geometry and the shape of the arterial cross section on inter facial shear.

Copyright © 1981 by ASME
Your Session has timed out. Please sign back in to continue.





Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In