0
RESEARCH PAPERS

Diffusion of Macromolecules Across the Arterial Wall in the Presence of Multiple Endothelial Injuries

[+] Author and Article Information
R. Pfeffer

Department of Chemical Engineering, The City College of The City University of New York, New York, N. Y. 10031

P. Ganatos, S. Weinbaum

Department of Mechanical Engineering, The City College of The City University of New York, New York, N. Y. 10031

A. Nir

Department of Chemical Engineering, The Technion-Israel Institute of Technology, Haifa, Israel

J Biomech Eng 103(3), 197-203 (Aug 01, 1981) (7 pages) doi:10.1115/1.3138278 History: Received June 15, 1981; Online June 15, 2009

Abstract

In this paper, the two-phase arterial wall model developed by Weinbaum and Caro [2] has been extended to obtain analytic solutions for the steady-state flux, uptake and concentration of macromolecules in the arterial wall due to the presence of periodically dispersed local sites of enhanced permeability. In the endothelial cell layer these sites are believed to be associated with the dying and regeneration of individual cells in the endothelial monolayer. Nir and Pfeffer [9] obtained similar solutions for a single dying cell in an otherwise undamaged endothelial cell layer. However this model requires that multiple cell turnover sites be spaced sufficiently far apart such that no interaction between neighboring sites takes place and hence cannot be applied to closely spaced endothelial injuries which have been observed experimentally in physiological studies. The theoretical predictions of the present model compare very favorably with experimental results for the enhanced uptake found in blue versus white areas reported in morphological studies of the endothelial surface (Bell, et al. [10, 11]).

Copyright © 1981 by ASME
Your Session has timed out. Please sign back in to continue.

References

Figures

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In