0
RESEARCH PAPERS

Vascular Endothelial Morphology as an Indicator of the Pattern of Blood Flow

[+] Author and Article Information
R. M. Nerem, M. J. Levesque

Physiological Fluid Mechanics Laboratory, Department of Mechanical Engineering, University of Houston, Houston, Tex. 77004

J. F. Cornhill

Division of Thoracic Surgery, Department of Surgery, Ohio State University, Columbus, Ohio 43210

J Biomech Eng 103(3), 172-176 (Aug 01, 1981) (5 pages) doi:10.1115/1.3138275 History: Received June 15, 1981; Online June 15, 2009

Abstract

A quantitative study of the en face size and shape of endothelial cells from aortic intercostal ostia has been carried out in rabbits. Photomicrographs were taken from vascular casts of the rabbit aorta and the endothelial cell outlines were analyzed quantitatively using a digitizer and digital computer. The morphology of the endothelial cells was described using 8 calculated parameters (area, perimeter, length, width, angle of orientation, width: length ratio, axis-intersection ratio and shape index). Marked changes in cell morphology were found in the regions proximal and distal to ostia as well as around flow dividers. Cells on the aorta are aligned with the flow direction, and the endothelial cells within the ostia have an angle of orientation of approximately 45 deg to the axis of the vessel. The results obtained to date suggest that endothelial cell morphology and orientation around a branch vessel may be a natural marker or indicator of the detailed features of blood flow.

Copyright © 1981 by ASME
Your Session has timed out. Please sign back in to continue.

References

Figures

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In