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RESEARCH PAPERS

The Concentration Polarization Effect in Frozen Erythrocytes

[+] Author and Article Information
R. L. Levin

Cryogenic Engineering Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Mass.; Biophysical Laboratory, Harvard Medical School, Boston, Mass.

E. G. Cravalho

Cryogenic Engineering Laboratory, Department of Mechanical Engineering; School of Engineering, Massachusetts Institute of Technology, Cambridge, Mass.

C. E. Huggins

Harvard Medical School; Low Temperature Surgical Unit, Blood Bank and Transfusion Service, Massachusetts General Hospital, Boston, Mass.

J Biomech Eng 99(2), 65-73 (May 01, 1977) (9 pages) doi:10.1115/1.3426275 History: Received March 15, 1977; Online October 21, 2010

Abstract

An ideal, hydrated, nondilute pseudo-binary solution model is presented to describe the concentration polarization of solutes within cells during osmotic experiments. This model has been applied to the case of hyman erythrocytes being cooled at subzero temperatures. The concentration polarization of solutes within the RBC intracellular solution during freezing reveals the fact that the water transport process is significantly affected not only by the permeation of water through the cell membrane, but also by the diffusion of water within the intracellular medium.

Copyright © 1977 by ASME
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